Experimental and Theoretical Evaluation of the Structure and Properties of New Stannyl Complexes of Pyridine Amide Ligands

Main Article Content

Raji Thomas
Pushpa Pardasani


Aims: Penta and tetra coordinated stannyl derivatives of N, N'-Bis(2-pyridyl)pyridine-2,6-dicarboxamide (H2L) and N-(pyridine-2-yl)picolinamide (HL1) have been synthesized. The structure of the complexes has been well established by Sn119 NMR and computational studies (GAUSSIAN 03 suit of programs). MESP and NBO studies have been carried out to understand different binding modes and properties of the complexes as well as ligands. The relative bond strengths have been estimated using the Wiberg bond index analysis.

Study Design:  Experimental and computational.

Place and Duration of Study: Department of Chemistry, University of Rajasthan, Jaipur, 2014.

Methodology: The structure of the complexes has been analyzed by IR and NMR. Computational studies (GAUSSIAN 03 suit of programs) have been used to elucidate the structure of the newly synthesized complexes.

Results: 119Sn NMR showed a pentacoordinate range for diamide complexes indicating coordination through the nitrogen of central pyridine ring in addition to amide nitrogens and tetracoordinate range for monoamide complexes confirming the formation of the products. The bonding properties have been confirmed by the computational calculations.

Conclusion: A series of dialkyl/diphenyl and trialkyl/triphenyl derivatives of organo tin complexes containing amide functionality have been synthesized and their structural characterizations performed by different spectral techniques and computational analysis.

Amide ligands, tin complexes, MESP, NBO

Article Details

How to Cite
Thomas, R., & Pardasani, P. (2019). Experimental and Theoretical Evaluation of the Structure and Properties of New Stannyl Complexes of Pyridine Amide Ligands. International Research Journal of Pure and Applied Chemistry, 19(3), 1-8. https://doi.org/10.9734/irjpac/2019/v19i330112
Original Research Article


Preeti R, Abhilekha S. Synthesis and biological importance of amide analogues, J Pharmacol Med Chem. 2018;2(2):22-31.

Vishal K, Vinod B, Neeraj K, Amides from plants: Structures and biological importance, studies in natural products chemistry. 2018;56:287-333.

Rajan P, Vedernikova I, Cos P, Berghe D V, Augustyns K, Haemers A, Synthesis and evaluation of caffeic acid amides as antioxidants, Bioorg. Med. Chem. Lett. 2001;11(2):215-217.

van Rijt SH, Hebden AJ, Amaresekera T, Deeth RJ, Clarkson GJ, Parsons S, McGowan PC, Sadler PJ. Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes, J. Med. Chem. 2009;52(23):7753-7764.

Harford C, Sarkar B, Amino Terminal Cu(II)- and Ni(II)-Binding (ATCUN) Motif of Proteins and Peptides: Metal binding, DNA cleavage and other properties, Acc. Chem. Res. 1997;30:123-130.

Mishra A, Kaushik NK, Verma AK, Gupta R. Synthesis, characterization and antibacterial activity of cobalt(III) complexes with pyridine–amide ligands, Eur. J. Med. Chem. 2008;43(10):2189-2196.

Narasimhan B, Belsare D, Pharande D, Mourya V, Dhake A, Esters, amides and substituted derivatives of cinnamic acid: synthesis, antimicrobial activity and QSAR investigations, Eur. J. Med. Chem. 2004; 39(10):827-834.

Al-Salahi RA, Al-Omar MA, Amr AEE, Synthesis of chiral macrocyclic or linear pyridine carboxamides from Pyridine-2,6-dicarbonyl dichloride as antimicrobial agents, molecules. 2010;15:6588-6597.

Cheng CC, Huang X, Shipps GW, Wang Y, Wyss DF, Soucy KA, Jiang C, Agrawal S, Ferrari E, He Z, Huang HC, Pyridine carboxamides: Potent palm site inhibitors of HCV NS5B polymerase, Med. Chem. Lett.,2010;1(9):466-471.

Vos D. De, Willem R, Gielen M, Van Wingerdin KE, Nooter K. The development of novel organotin anti-tumor drugs: Structure and activity. Metal-based Drugs. 1998;5(4):179-188.

Gielen M, Coord. Chem. Rev. Tin-based antitumour drugs. 1996;151:41.

Raji T, Nelson JP, Pushpa P, Mukherjee T. Synthesis and properties of the alkyl/aryl germanium dioximates containing Ge O bond: Stability factors–A theoretical Approach, Heteroatom Chem. 2012;23(6): 545-550.

Raji T, Nelson JP, Ramchand TP, Pushpa P, Mukherjee T. Novel tin complexes containing an oximato ligand: Synthesis, characterization and computational investigation. Helvetica Chimica Acta. 2013;96:1740-1749.

Pardasani P, Kumar D. Synthesis and structural features of Organotinnaphthoquinolates and regiochemistry of their diels-alder cycloadducts, Main Group Met Chem. 2004;27(4):233-240.

Sharma M, Pardasani P. Synthesis and characterization of Dialkyl-/diphenyltin(IV) complexes derived from Acenaphthenequinone Monooxime, Main Group Met. Chem. 2008;31:227-234.

Armarego WLF, Perrin DD. Purification of laboratory chemicals, 4th Edn, Butterworth, Oxford; 1997.

Vogel AI. Textbook of quantitative chemical analysis, 4th edn., Longman, London; 1989.