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An Randamised Block Design (RBD) field investigation with ten crop sequences under irrigation with recommended package of practices in sandy loam soils of Southern Telangana Zone (STZ), Telangana was carried out during Kharif, Rabi and summer of 2018-2019 with an objective of the nutrient uptake and soil fertility status under different cropping systems and to assess agro economic benefit. These ten cropping systems were grouped in to five categories viz., pre dominant cropping systems of the zone, ecological cropping systems, household nutritional security giving cropping systems, fodder security giving cropping systems and cropping systems involving high value crops. So that from each category, best cropping system can be identified and can be suggested to different integrated farming systems models. In the context of farming systems, under high value crops such as Okra–Marigold–Beetroot system recorded significantly higher rice grain equivalent yield (36,434 kg ha-1) over other systems. Among the ecological cropping systems for improving soil health, Bt cotton + green gram (1:3) - groundnut cropping system was recorded significantly higher rice grain equivalent yield (14,080 kg ha-1) as compared to pigeon pea + green gram (1:7) – sesame cropping system. Among the household nutritional security giving crops, pigeon pea + maize (1:3) – groundnut system was recorded higher rice grain equivalent yield (13,693 kg ha-1). Within the two fodder crops, fodder maize – lucerne system was resulted in higher rice grain equivalent yield (7,709 kg ha-1). Rice - maize and Bt cotton which were the pre-dominant cropping systems of the region wherein rice – maize system recorded comparatively higher rice grain equivalent yield (11,771 kg ha-1) than Bt cotton. Fodder systems were found to be more exhaustive than all other cropping systems. However, within two years of experimentation the changes in physic-chemical properties and soil fertility status were not significantly affected except organic carbon. Organic carbon was high (0.45 %) in case of pigeon pea + green gram (1:6) - sesame cropping system.
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