Nano Emulsion: The Targeted Drug Delivery in the Therapy of Epilepsy

N. V. L. Suvarchala Reddy V. *

Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana, India.

M. Ganga Raju

Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana, India.

Keerthana Edunoori

Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana, India.

Jyothi Papani

Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana, India.

*Author to whom correspondence should be addressed.


Abstract

Around the world, 50 million people suffer with epilepsy; it significantly burdens society in terms of finances, society, and health. Our comprehension of the pathophysiological processes causing the illness and the factors affecting its prognosis has significantly advanced during the last ten years. Around a third of patients are still resistive to medical intervention, despite the fact that the number of antiepileptic drugs has expanded dramatically over the past 20 years. The ability of nanotech-based anti-epileptic drug (AED) administration methods to cross the blood brain barrier, increase specificity, and have the capacity for extended brain administration of drugs have lately attracted interest. Nanotechnology appears to be a promising and innovative development in this area. Nano emulsions have a mean droplet size of 20 to 200 nm and remain kinetically stable dispersions of two incompatible liquids with the assistance of an emulsifier or emulsifiers. The effectiveness of NEs as a delivery system for Central Nervous System-active medications used in effective regimens against difficult-to-treat CNS conditions.

Keywords: Epilepsy, types of seizures, antiepileptic drugs, nanoemulsions


How to Cite

N. V. L. Suvarchala Reddy V., M. Ganga Raju, Keerthana Edunoori, and Jyothi Papani. 2023. “Nano Emulsion: The Targeted Drug Delivery in the Therapy of Epilepsy”. International Research Journal of Pure and Applied Chemistry 24 (5):46-53. https://doi.org/10.9734/irjpac/2023/v24i5824.

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References

Avanthi E, Pradeep Kumar L, Lokesh BN, Yadavalli Guruprasad. The study of antiepileptic activity of clove oil by MES model in mice. Indian Journal of Pharmacy and Pharmacology. 2016;3(3); 103-107.

World Health Organization. Global status report on alcohol and health 2018. World Health Organization; 2019.

Neligan A, Hauser WA, Sander JW. The epidemiology of the epilepsies. Handbook of clinical neurology. 2012;107:113- 33.

Ghosh S, Sinha JK, Khan T, Devaraju KS, Singh P, Vaibhav K, Gaur P. Pharmacological and therapeutic approaches in the treatment of epilepsy. Biomedicines. 2021;9(5):470.

Shringarpure M, Gharat S, Momin M, Omri A. Management of epileptic disorders using nanotechnology-based strategies for nose-to-brain drug delivery. Expert Opinion on Drug Delivery. 2021;18(2):169- 85.

Moshé SL, Perucca E, Ryvlin P, Tomson T. Epilepsy: new advances. The Lancet. 2015;385(9971):884-98.

Birhan YS. Medicinal plants utilized in the management of epilepsy in Ethiopia: ethnobotany, pharmacology and phyto-chemistry. Chinese Medicine. 2022;17(1): 1-37.

Devinsky O, Vezzani A, O'Brien TJ, Jette N, Scheffer IE, de Curtis M, Perucca P. Epilepsy (primer). Nature Reviews: Disease Primers. 2018;4(1).

Beghi E. The epidemiology of epilepsy. Neuroepidemiology. 2020;54(2):185- 91.

Patil MV, Kandhare AD, Ghosh P, Bhise SD. Determination of role of GABA and nitric oxide in anticonvulsant activity of Fragaria vesca L. ethanolic extract in chemically induced epilepsy in laboratory animals. Oriental Pharmacy and Experimental Medicine. 2012;255- 64.

Rogawski MA, Löscher W. The neurobiology of antiepileptic drugs. Nature reviews neuroscience. 2004;5(7):553- 64.

El-Missiry MA, Othman AI, Amer MA, Sedki M, Ali SM, El-Sherbiny IM. Nanoformulated ellagic acid ameliorates pentylenetetrazol-induced experimental epileptic seizures by modulating oxidative stress, inflammatory cytokines and apoptosis in the brains of male mice. Metabolic Brain Disease. 2020;35:385-99.

Lovelyn C, Attama AA. Current state of nanoemulsions in drug delivery. Journal of Biomaterials and Nanobiotechnology. 2011;2(05):626.

Nirale P, Paul A, Yadav KS. Nanoemulsions for targeting the neurodegenerative diseases: Alzheimer's, Parkinson's and Prion's. Life sciences. 2020;245:117394.

Wilson RJ, Li Y, Yang G, Zhao CX. Nanoemulsions for drug delivery. Particuology. 2022;64:85-97.

Harun SN, Nordin SA, Gani SS, Shamsuddin AF, Basri M, Basri HB. Development of nanoemulsion for efficient brain parenteral delivery of cefuroxime: Designs, characterizations,

Sepasi T, Ghadiri T, Bani F, Ebrahimi-Kalan A, Khodakarimi S, Zarebkohan A, Gorji A. Nanotechnology-based approaches in diagnosis and treatment of epilepsy. Journal of Nanoparticle Research. 2022; 24(10):199.

Jaiswal M, Dudhe R, Sharma PK. Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech. 2015;123- 7.

Majeed A, Bashir R, Farooq S, Maqbool M. Preparation, characterization and applications of nanoemulsions: An insight. Journal of Drug Delivery and Therapeutics. 2019;9(2):520-7.

Harwansh RK, Deshmukh R, Rahman MA. Nanoemulsion: Promising nanocarrier system for delivery of herbal bioactives. Journal of Drug Delivery Science and Technology. 2019;51:224-33.

Kumar M, Bishnoi RS, Shukla AK, Jain CP. Techniques for formulation of nanoemulsion drug delivery system: a review. Preventive nutrition and food science. 2019;24(3):225.

Gupta A, Eral HB, Hatton TA, Doyle PS. Nanoemulsions: formation, properties and applications. Soft matter. 2016;12(11): 2826-41.

Patel RJ, Parikh RH. Intranasal delivery of topiramate nanoemulsion: Pharmaco-dynamic, pharmacokinetic and brain uptake studies. International Journal of Pharmaceutics. 2020;585:119486.

Iqbal R, Ahmed S, Jain GK, Vohora D. Design and development of letrozole nanoemulsion: A comparative evaluation of brain targeted nanoemulsion with free letrozole against status epilepticus and neurodegeneration in mice. International journal of pharmaceutics. 2019;565:20- 32.

Ahmad N, Ahmad R, Alam MA, Ahmad FJ, Amir M. Retracted Article: Impact of ultrasonication techniques on the preparation of novel Amiloride-nanoemulsion used for intranasal delivery in the treatment of epilepsy. Artificial Cells, Nanomedicine, and Biotechnology. 2018; 46(Sup 3):192-207.

Thuraisingam S, Salim N, Azmi ID, Kartinee N. Development of nanoemulsion containing Centella asiatica crude extract as a promising drug delivery system for epilepsy treatment. Biointerface Res. Appl. Chem. 2022;13(17):10-33263.

Nogueira C, Lemos-Senna E, da Silva Vieira E, Sampaio TB, Mallmann MP, Oliveira MS, Bernardi LS, Oliveira PR. β-caryophyllene cationic nanoemulsion for intranasal delivery and treatment of epilepsy: development and in vivo evaluation of anticonvulsant activity. Journal of Nanoparticle Research. 2023; 25(1):19.

Chircov C, Grumezescu AM. Nanoemulsion preparation, characterization, and application in the field of biomedicine. In Nanoarchitectonics in biomedicine. 2019;169-188. William Andrew Publishing.

Kim CK, Cho YJ, Gao ZG. Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery. Journal of controlled release. 2001;70(1-2):149-55.

Simonazzi A, Cid AG, Villegas M, Romero AI, Palma SD, Bermúdez JM. Nanotechnology applications in drug controlled release. In Drug targeting and stimuli sensitive drug delivery systems. William Andrew Publishing. 2018;81- 116.

Nishitani Yukuyama M, Tomiko Myiake Kato E, Lobenberg R, Araci Bou-Chacra N. Challenges and future prospects of nanoemulsion as a drug delivery system. Current Pharmaceutical Design. 2017; 23(3):495-508.

Halnor VV, Pande VV, Borawake DD, Nagare HS. Nanoemulsion: A novel platform for drug delivery system. J Mat Sci Nanotechol. 2018;6(1):104.

Vashi K, Pathak YY. Challenges in targeting to brain and brain tumors. InNanocarriers for Drug-Targeting Brain Tumors. Elsevier. 2022;51-68.