A Review on Synthesis, Lanthanide Complexes and Biological Activites of Hydrazone Derivatives of Hydrazinecarbothioamides
Ugochukwu. B. Amadi *
Chemistry Research Unit Department, SLT Akanu Ibiam Federal Polytechnic, Unwana, Ebonyi State, Nigeria.
Martin. O. C. Ogwuegbu
Department of Chemistry, Federal University of Technology, Owerri, Imo State, Nigeria.
Conrad. K. Enenebeaku
Department of Chemistry, Federal University of Technology, Owerri, Imo State, Nigeria.
Gerald. O. Onyedika
Department of Chemistry, Federal University of Technology, Owerri, Imo State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Hydrazinecarbothioamides are important intermediates with biological activities in organic chemistry synthesis, especially in the synthesis of biologically active heterocyclic scaffolds and compounds. The uniqueness in of synthesis and a wild range of pharmaceutical, medicinal biological potentials and properties, their preferred application as building brick in and the synthesis of heterocyclic and other important organic compounds and nonlinear optical (NLO) materials have made them attractive derivatives of thiosemicarbazides in the recent years. In this review, a detailed account in terms of synthesis and applications of their hydrazone derivatives and their lanthanide complexes are presented .Further, the biological and analytical applications of newly reported ligands and their complexes are reported. The wide investigation of the lanthanide (III) coordination complexes with organic ligands are mainly due to their structures and strong potential biological and pharmacological properties of hydrazones as derivatives of hydrazinecarbothioamides possess sites that play important roles in the formation of heterocyclics and other biologically active scaffolds.
Keywords: Analytical applications, biological applications, hydrazinecarbothioamide, lanthanide complexes, thiosemicarbazide