https://journalirjpac.com/index.php/IRJPAC <p style="text-align: justify;"><strong>International Research Journal of Pure and Applied Chemistry (ISSN: <a href="https://nsl.niscpr.res.in/ISSNPROCESS/issnassignedinfo.jsp">2231-3443</a>)</strong> aims to publish original research articles, review articles and short communications in all aspects of pure and applied chemistry including analytical chemistry, biochemistry, medicinal chemistry, molecular biology and genetics, inorganic chemistry, organometallic chemistry, materials chemistry, chemistry of solids, liquids, polymers and interfaces between different phases, neurochemistry, nuclear chemistry, modern transmutation, organic chemistry, physical chemistry, phytochemistry, polymer chemistry, supramolecular and macromolecular chemistry, chemical thermodynamics, chemical kinetics, electrochemistry, statistical mechanics, spectroscopy, astrochemistry and cosmochemistry, quantum chemistry and theoretical chemistry, sonochemistry, agrochemistry, atmospheric chemistry, chemical engineering, chemical biology, chemo-informatics, electrochemistry, femtochemistry, geochemistry, green chemistry, histochemistry, immunochemistry, marine chemistry, mechanochemistry, nanotechnology, natural product chemistry, oenology, petrochemistry, pharmacology, photochemistry, radiochemistry, synthetic chemistry, kinetics and mechanisms of chemical reactions, thermochemistry, chemistry in industry and interactions between chemistry and environment. </p> en-US [email protected] (International Research Journal of Pure and Applied Chemistry) [email protected] (International Research Journal of Pure and Applied Chemistry) Thu, 01 Oct 2026 13:53:23 +0000 OJS 3.3.0.21 http://blogs.law.harvard.edu/tech/rss 60 https://journalirjpac.com/index.php/IRJPAC/article/view/1041 <p>The leaves of <em>Capparis sepiaria</em> and <em>Maerua angolensis</em> are consumed by some populations in Burkina Faso and are traditionally associated with gastrointestinal uses. This study evaluated the anti-ulcer and analgesic activities of aqueous leaf extracts of both plants in mice. Gastroprotective activity was assessed using ethanol-induced gastric ulcer models under acute and chronic conditions, while analgesic activity was evaluated using acetic acid-induced abdominal contortions. In the acute model, <em>Capparis</em> <em>sepiaria</em> extract at 500 mg/kg produced 92% protection of the gastric mucosa, compared with 96% for sucralfate. The ulcer index decreased from 10 at 300 mg/kg to 4.83 at 500 mg/kg for <em>Capparis sepiaria</em>. In the chronic model, the ulcer index decreased from 0.83 in the ulcer control to 0.08 with selected extract treatments, and extracts of both plants showed a better healing of ulcer lesions at all tested doses after seven days of treatment. Analgesic activity increased with dose. At 500 mg/kg, <em>Maerua angolensis</em> produced 75% inhibition of acetic acid-induced abdominal contortions, equal to the inhibition observed with paracetamol at 100 mg/kg. These findings indicate that the leaf extracts exhibited gastroprotective, ulcer-healing, and analgesic activities under the experimental conditions used. They provide a scientific basis for further evaluation of these plants for the development of improved traditional medicines or nutraceutical applications for gastrointestinal disorders.</p> David Bado, Alphonsine Ramde-Tiendrebeogo, Nabere Ouattara, Mathieu Nitiema, Tata Kadiatou Traore, Abdoul Gilchrist Laurent Boly, Vincent Rouamba, Moussa Compaore, Noufou Ouedraogo, Martin Kiendrebeogo, Innocent Pierre Guissou Copyright (c) 2026 Author(s). The licensee is the journal publisher. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0 https://journalirjpac.com/index.php/IRJPAC/article/view/1041 Thu, 01 Oct 2026 00:00:00 +0000