One-pot Multi-component Synthesis of Some Pharmacologically Significant 2,4,5-Tri and 1,2,4,5-Tetrasubstituted Imidazoles: A Review
Ravi Bansal *
School of Studies in Chemistry, Jiwaji University, Gwalior (M.P.)-474011, India
Pradeep K. Soni
School of Studies in Chemistry, Jiwaji University, Gwalior (M.P.)-474011, India
Mukesh K. Ahirwar
Govt. Maharaja Autonomous P.G. College, Chhatarpur (M.P.), India
Anand K. Halve
School of Studies in Chemistry, Jiwaji University, Gwalior (M.P.)-474011, India
*Author to whom correspondence should be addressed.
Abstract
Heterocyclic compounds are acquiring more importance in recent years because of their pharmacological activities. Compounds containing imidazole moiety have many pharmacological properties and play important role in biochemical processes. Imidazole is a natural compound which exists in many important natural molecules such as the amino acid histidine, vitamin B12, histamine, biotin and purines like adenine and guanine. Imidazole derivatives play significant roles in various pharmacological activities such as anticancer, antibacterial, antifungal, antiviral, anti-HIV and antitubercular. This article aims to review the work in the methods of synthesis using various catalytic system, solvent condition and pharmacological potential of 2,4,5-tri and 1,2,4,5-tetrasubstituted imidazoles reported during last 15 years.
Keywords: Multi-component reactions, heterocycles, substituted imidazoles, pharmacological activities