Synthesis of New 1,2,4-Triazoles Containing Oxadiazole Moiety: Potential Intermediates for Preparation of Ribavirin Analogues
Tatyana Sharonova
The Ushinsky Yaroslavl State Pedagogical University, Yaroslavl, Russia
Sergey Baykov *
The Ushinsky Yaroslavl State Pedagogical University, Yaroslavl, Russia
Mikhail Dorogov
The Ushinsky Yaroslavl State Pedagogical University, Yaroslavl, Russia
*Author to whom correspondence should be addressed.
Abstract
In this paper, we report synthesis of the new biheterocycles containing 1,2,4-triazole and 1,2,4-oxadiazole or 1,3,4-oxadiazole moiety. Oxadiazole ring is bioisosteric replacement of carboxamide group. In future, these compounds will be used for enzymatic synthesis of ribavirin analogues. Structures of the final biheterocycles were confirmed by spectral and elemental analysis.
Keywords: 1,2,4-triazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole, bioisosteric replacement, ribavirin