Synthesis and In vitro Antimicrobial Activity of New Schiff Bases of 1,3,4-thiadiazole and 1,2,4-triazole
Łukasz Popiołek *
Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland
Magdalena Matraszek
Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland
Paulina Piasecka
Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland
Klaudia Pataj
Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland
Marcin Bińczak
Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland
Mateusz Celiński
Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland
Anna Biernasiuk
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland
*Author to whom correspondence should be addressed.
Abstract
This study presents the synthesis, spectral analysis and in vitro antimicrobial evaluation of a new series of Schiff bases of 1,3,4-thiadiazole and 1,2,4-triazole (1-10). The structure of obtained compounds was confirmed by spectral analysis (IR, 1H NMR and 13C NMR) and elemental analysis. All synthesized compounds were screened for their in vitro antimicrobial activities using the broth microdilution method against a panel of bacterial strains including Gram-positive bacteria, Gram-negative bacteria and yeasts belonging to Candidas pp.
Keywords: Schiff bases, 1,3,4-thiadiazole derivatives, 1,2,4-triazole derivatives, antibacterial activity, antifungal activity, MIC