Cyclic Voltammetric Study of Losartan Potassium
S. Azhar Ali
Department of Chemistry, University of Karachi, Karachi, Pakistan 7520. Pakistan
Atya Hassan *
Federal Urdu University of Arts, Science and Technology, Gulshan Iqbal Campus Karachi, Karachi, Pakistan
*Author to whom correspondence should be addressed.
Abstract
Cyclic voltammetric technique has been used for investigation of electrochemical parameters of antihypertensive drug, Losartan Potassium. This drug is usually used for the treatment of blood pressure, type II diabetic disease with proteinuria and stroke prevention. In this study Britton Robinson buffer was used as supporting electrolyte at room temperature30±1ºC and peak potential (Epc), Peak current(Ipc), transfer coefficient (α) and diffusion coefficient (D) were estimated at different scan rates, pH and concentration. The electrochemical process was found to be adsorption controlled and irreversible. Furthermore, Losartan Potassium represents transfer of two electrons during reduction reaction.
Keywords: Cyclic voltammetry, Losartan Potassium, Electrochemical parameters, Gold electrode, Antihypertensive drug