Synthesis of Organometallic-Based Biologically Active Compounds: In vitro Antibacterial and Antifungal of Asymmetric Ferrocene-Derived Schiff-Bases Chelates
W. H. Hegazy *
Faculty of Science, Suez-Canal University, Suez, Egypt and College of Science, King Faisal University, Saudi Arabia
*Author to whom correspondence should be addressed.
Abstract
Asymmetric 1,1`-disubstituted ferrocene-derived Schiff-bases have been prepared and used as ligands in the preparation of their novel Pd(II) and Pt(IV) metal chelates. The synthesized ligands and their metal chelates have been characterized by their physical, analytical and spectral data. These have also been used for screening against B. subtilis, S. aureus, E. coli, S. typhi (bacteria), C. albicans (yeast), A. niger and F. solani (fungi). The antimicrobial results indicated that the chelates prepared are more active than the ligand and have been found to be a novel class of organometallic-based antimicrobials.
Keywords: Ferrocene-derived Schiff bases ligands, Palladium (II) chelates, Platinum (IV) chelates, Organometallic-based antimicrobials