Isotopic Self - Programming for the Embryonic Cell DNA Methylation Pattern
Andrey A. Ivanov *
V. I. Vernadsky Institute for Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Kosygin St. 19, Moscow 117975, Russian Federation
*Author to whom correspondence should be addressed.
Abstract
This paper is an original attempt to analyze a series of experimental data obtained lately by the author in a course of his long term studies on the probable role of isotopy in the molecular evolution of living systems as well as in the eukaryotic cell differentiation mechanisms. A dependence of the DNA double helix methylation process on the surrounding media / threads isotope composition is in a focus of the concept presented.
Keywords: DNA methylation, DNA replication, C13-isotope effects, cell differentiation