Optimization of Synthesis Process of 4-Methylquinazoline
Juan Liu
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China
Yun Yang
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China
Liangchun Li *
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China
*Author to whom correspondence should be addressed.
Abstract
4-Methylquinazoline was synthesized with 2-aminoacetophenone and formamide as the starting materials. The reaction conditions, including catalyst, ratio of substrates, temperature and time were optimized. Results showed that the optimal condition were as follows: Catalyst BF3-Et2O, the molar ratio of 2-aminoacetophenone: BF3-Et2O = 1:0.5, the weight ratio of 2-aminoacetophenone: formamide = 1:52, temperature 150°C, and time 6 h. Under the optimal conditions, the yield of the reaction achieved the highest (86%), which are better than the past reports.
Keywords: Quinazolines, 4-methylquinazoline, synthesis, Lewis acid, reaction condition