PICT Effects and Anticancer Potential on Rosaniline and Spectral Characterisation of Rosaniline/ Cyclodextrin Covered ZnO/ Nanocrystals
Palanichamy Ramasamy
Department of Chemistry, Annamalai University, Annamalai Nagar, India.
Ayyadurai Mani
Center for Advanced Energy Materials, SRM TRP Engineering College, Tiruchy, India.
Albert Antony Muthu Prabhu
Department of Chemistry, Aditanar College of Arts and Science, Tiruchendur, India.
Govindaraj Venkatesh
Department of Chemistry, Knowledge Institute of Technology (Autonomous), Salem, India.
Poomalai Senthilraja
Department of Bioinformatics, Bharathidasan University, Tiruchy, India.
Narayanasamy Rajendiran
*
Department of Chemistry, Annamalai University, Annamalai Nagar, India.
*Author to whom correspondence should be addressed.
Abstract
Rosaniline/Cyclodextrin covered ZnO nanocrystals are synthesized and characterized by various spectral and microscopic methods. The effect of different polarities of the solvents, α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) on RND was studied by various spectral methods. The inclusion behavior of RND on both CDs was determined by PM3 method. The doping effect of RND/CD on ZnO nano investigated by UV-visible, fluorescence, FTIR, DTA, XRD, FE-SEM and TEM methods. RND molecules exhibit single emission in non-polar and aprotic solvents, whereas in water, α-CD and β-CD exhibit dual emission. Solvent and PM3 studies indicate planar intramolecular charge transfer (PICT) in RND molecules. Absence of an isosbestic point suggests a 1:2 or 1:3 inclusion complex is formed. HOMO-LUMO gap for RND/β-CD inclusion complex was more negative, which supports that this complex is more stable than RND/α-CD inclusion complex. Compared to RND/CD inclusion complex, a red or blue shifted absorption and fluorescence maximum was seen in β-CD/RND doped ZnO nanocrystals. Nanoparticle size was measured by TEM-EDS and XRD methods. Molecular docking studies shows, RND has anticancer activity against 2oh4 interacting amino acid residues.
Keywords: Rosaniline, zinc oxide nano, cyclodextrin, planar intramolecular charge transfer, inclusion complex, nanocrystal