International Research Journal of Pure and Applied Chemistry

Ultrasonic velocity (u), density (r), refractive index (n) and relative viscosity (h_r) measurements were carried out for ranitidine hydrochloride in aqueous-sodium chloride/sucrose solutions at 30°C in order to understand the effect of electrolyte and non-electrolyte on physicochemical behaviour of aqueous-ranitidine hydrochloride solution. The measured and derived properties such as apparent molar volumes (V_2,j), isentropic compressibility (k_s), apparent molar isentropic compressibility (k_S,_2,f) and specific acoustic impedance (Z) have been analyzed in terms of structure and different interactions in studied solutions. The limiting partial molar volumes (V₂^o_,f) of drug have been determined from the Massons relation and standard transfer volume (D_tV₂^o_,f) were also computed and interpreted for their sign and magnitude for different systems. The relative viscosity data has been analyzed by the Jones-Dole linear fitting relation and viscosity-A and B coefficients were determined and used to understand the solute-solute and solute-solvent interactions.